Tumor Biology and Research Lab
Living biosamples for translational tumor biology research
Introducing the
research department
The Tumor Biology and Research Lab integrates biosample collection and preservation with translational research. Special attention is paid to cultivating the patient’s own tissue as organoids under S2 laboratory conditions in order to use these miniaturized 3D cell models for cancer research and the development of personalized cancer therapy.
Together with other systematically collected biosamples from the patient, the “living biobank” established in this way opens up a new approach to research: using modern methods such as longitudinal light sheet microscopy and molecular biological analysis, we are improving our understanding of the development and treatment of cancer. The aim is to develop individually tailored therapy strategies that increase effectiveness and tolerability and minimize the occurrence of recurrences.
Research Team
Dr. rer. nat. Chaolie Huang
Research Associate
Dr. rer. nat. Martin Jechlinger
Senior Scientist
Praveena Kothapalli
Lab technician
Philip Mbonu
Lab technician
Muthu Kumaran Umapathy
Lab technician
Publications
Current Publications
3757376
ZWEHBPD6
1
apa
3
date
desc
4598
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Starostecka, M., Jeong, H., Hasenfeld, P., Benito-Garagorri, E., Christiansen, T., Stober Brasseur, C., Gomes Queiroz, M., Garcia Montero, M., Jechlinger, M., & Korbel, J. O. (2025). Structural variant and nucleosome occupancy dynamics postchemotherapy in a HER2+ breast cancer organoid model. Proceedings of the National Academy of Sciences of the United States of America, 122(9), e2415475122. https://doi.org/10.1073/pnas.2415475122
Yang, F., Bevilacqua, C., Hambura, S., Neves, A., Gopalan, A., Watanabe, K., Govendir, M., Bernabeu, M., Ellenberg, J., Diz-Muñoz, A., Köhler, S., Rapti, G., Jechlinger, M., & Prevedel, R. (2024). Author Correction: Pulsed stimulated Brillouin microscopy enables high-sensitivity mechanical imaging of live and fragile biological specimens. Nature Methods, 21(5), 922. https://doi.org/10.1038/s41592-024-02259-w
Yang, F., Bevilacqua, C., Hambura, S., Neves, A., Gopalan, A., Watanabe, K., Govendir, M., Bernabeu, M., Ellenberg, J., Diz-Muñoz, A., Köhler, S., Rapti, G., Jechlinger, M., & Prevedel, R. (2023). Pulsed stimulated Brillouin microscopy enables high-sensitivity mechanical imaging of live and fragile biological specimens. Nature Methods, 20(12), 1971–1979. https://doi.org/10.1038/s41592-023-02054-z
Services
A broad range of patient-specific samples and
functional assays for translational research
The following services are under development:
We will offer a catalog of high-quality biological samples stratified by a variety of molecular and patient-specific metadata, furthermore our functional assays can be made available for deeper insights into the molecular mechanisms of tumor biology.
More information to follow.
Current projects from Tumor Biology & Research Lab
Minimal residual disease (MRD)
In our research, we investigate the molecular patterns of resistant cell clones in order to identify the causes of this resistance – a crucial step for long-term therapeutic success.
Longitudinales imaging for organoids
Longitudinal live cell imaging enables the tracking of individual cells in 3D structures/organoids and provides insights into cell behavior, clonal dynamics and therapy responses.
German GASTrointestinal CanceR RegistrY (GASTRY)
The GASTRY study is a study to record clinical, biological and quality of life parameters in patients with advanced or metastatic gastrointestinal tumors.
MiTi-SECC study
The MiTi-SECC research project investigates the role of the intestinal microbiome on the course of disease and treatment success of colorectal cancer.